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BMCBI
2010
115views more  BMCBI 2010»
13 years 9 months ago
Multiconstrained gene clustering based on generalized projections
Background: Gene clustering for annotating gene functions is one of the fundamental issues in bioinformatics. The best clustering solution is often regularized by multiple constra...
Jia Zeng, Shanfeng Zhu, Alan Wee-Chung Liew, Hong ...
BMCBI
2010
152views more  BMCBI 2010»
13 years 9 months ago
A high-throughput de novo sequencing approach for shotgun proteomics using high-resolution tandem mass spectrometry
Background: High-resolution tandem mass spectra can now be readily acquired with hybrid instruments, such as LTQ-Orbitrap and LTQ-FT, in high-throughput shotgun proteomics workflo...
Chongle Pan, Byung-Hoon Park, William H. McDonald,...
BMCBI
2010
105views more  BMCBI 2010»
13 years 9 months ago
A knowledge-guided strategy for improving the accuracy of scoring functions in binding affinity prediction
Background: Current scoring functions are not very successful in protein-ligand binding affinity prediction albeit their popularity in structure-based drug designs. Here, we propo...
Tiejun Cheng, Zhihai Liu, Renxiao Wang
BMCBI
2010
277views more  BMCBI 2010»
13 years 9 months ago
PCA2GO: a new multivariate statistics based method to identify highly expressed GO-Terms
Background: Several tools have been developed to explore and search Gene Ontology (GO) databases allowing efficient GO enrichment analysis and GO tree visualization. Nevertheless,...
Marc Bruckskotten, Mario Looso, Franz Cemic, Anne ...
BMCBI
2010
89views more  BMCBI 2010»
13 years 9 months ago
Enhancing metabolomic data analysis with Progressive Consensus Alignment of NMR Spectra (PCANS)
Background: Nuclear magnetic resonance spectroscopy is one of the primary tools in metabolomics analyses, where it is used to track and quantify changes in metabolite concentratio...
Jennifer M. Staab, Thomas M. O'Connell, Shawn M. G...
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