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» Evolutionary Approaches to DNA Sequencing with Errors
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BMCBI
2008
132views more  BMCBI 2008»
13 years 8 months ago
The Average Mutual Information Profile as a Genomic Signature
Background: Occult organizational structures in DNA sequences may hold the key to understanding functional and evolutionary aspects of the DNA molecule. Such structures can also p...
Mark Bauer, Sheldon M. Schuster, Khalid Sayood
RECOMB
2001
Springer
14 years 8 months ago
A new approach to fragment assembly in DNA sequencing
For the last twenty years fragment assembly in DNA sequencing followed the "overlap - layout - consensus" paradigm that is used in all currently available assembly tools...
Pavel A. Pevzner, Haixu Tang, Michael S. Waterman
WABI
2009
Springer
142views Bioinformatics» more  WABI 2009»
14 years 3 months ago
Back-Translation for Discovering Distant Protein Homologies
Background: Frameshift mutations in protein-coding DNA sequences produce a drastic change in the resulting protein sequence, which prevents classic protein alignment methods from ...
Marta Gîrdea, Laurent Noé, Gregory Ku...
BMCBI
2005
97views more  BMCBI 2005»
13 years 8 months ago
Evolutionary distance estimation and fidelity of pair wise sequence alignment
Background: Evolutionary distances are a critical measure in comparative genomics and molecular evolutionary biology. A simulation study was used to examine the effect of alignmen...
Michael S. Rosenberg
JCB
2000
105views more  JCB 2000»
13 years 8 months ago
A Greedy Algorithm for Aligning DNA Sequences
For aligning DNA sequences that differ only by sequencing errors, or by equivalent errors from other sources, a greedy algorithm can be much faster than traditional dynamic progra...
Zheng Zhang 0004, Scott Schwartz, Lukas Wagner, We...