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BMCBI
2004
150views more  BMCBI 2004»
13 years 7 months ago
Inter-residue distances derived from fold contact propensities correlate with evolutionary substitution costs
Background: The wealth of information on protein structure has led to a variety of statistical analyses of the role played by individual amino acid types in the protein fold. In p...
Gareth Williams, Patrick Doherty
GECCO
2008
Springer
164views Optimization» more  GECCO 2008»
13 years 8 months ago
Genetic algorithms with local search optimization for protein structure prediction problem
This paper presents a new Genetic Algorithm for Protein Structure Prediction problem in both 2D and 3D hydrophobichydrophilic lattice models, introduced in [1]. Our algorithm evol...
Igor Berenboym, Mireille Avigal
BIOCOMP
2009
13 years 8 months ago
Evidence against the Paradigm of Energy Minimization in Protein Design
Abstract-- Stating protein design as an energy minimization in the space of amino acid sequences and rotamer combinations is usual. In the current paper an evolutionary algorithm b...
Andrea Bazzoli, Andrea Tettamanzi
ISBRA
2010
Springer
13 years 5 months ago
Residue Contexts: Non-sequential Protein Structure Alignment Using Structural and Biochemical Features
The study of non-sequential alignments, with different connectivity of the aligned fragments in the proteins being compared can offer a more complete picture of the structural, evo...
Jay W. Kim, Rahul Singh
CSB
2005
IEEE
124views Bioinformatics» more  CSB 2005»
14 years 1 months ago
Multi-Scale Hierarchical Structure Prediction of Helical Transmembrane Proteins
As the first step toward a multi-scale, hierarchical computational approach for membrane protein structure prediction, the packing of transmembrane helices was modeled at the resi...
Zhong Chen, Ying Xu