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BMCBI
2008
90views more  BMCBI 2008»
13 years 10 months ago
Genome-scale study of the importance of binding site context for transcription factor binding and gene regulation
Background: The rate of mRNA transcription is controlled by transcription factors that bind to specific DNA motifs in promoter regions upstream of protein coding genes. Recent res...
Jakub Orzechowski Westholm, Feifei Xu, Hans Ronne,...
BMCBI
2010
175views more  BMCBI 2010»
13 years 10 months ago
Global parameter estimation methods for stochastic biochemical systems
Background: The importance of stochasticity in cellular processes having low number of molecules has resulted in the development of stochastic models such as chemical master equat...
Suresh Kumar Poovathingal, Rudiyanto Gunawan
BMCBI
2010
117views more  BMCBI 2010»
13 years 10 months ago
MetAssimulo: Simulation of Realistic NMR Metabolic Profiles
Background: Probing the complex fusion of genetic and environmental interactions, metabolic profiling (or metabolomics/metabonomics), the study of small molecules involved in meta...
Harriet J. Muncey, Rebecca Jones, Maria De Iorio, ...
BMCBI
2010
182views more  BMCBI 2010»
13 years 10 months ago
Beyond co-localization: inferring spatial interactions between sub-cellular structures from microscopy images
Background: Sub-cellular structures interact in numerous direct and indirect ways in order to fulfill cellular functions. While direct molecular interactions crucially depend on s...
Jo A. Helmuth, Grégory Paul, Ivo F. Sbalzar...
BMCBI
2010
85views more  BMCBI 2010»
13 years 10 months ago
Robust test method for time-course microarray experiments
Background: In a time-course microarray experiment, the expression level for each gene is observed across a number of time-points in order to characterize the temporal trajectorie...
Insuk Sohn, Kouros Owzar, Stephen L. George, Sujon...
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