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BMCBI
2008
96views more  BMCBI 2008»
13 years 9 months ago
Use of normalization methods for analysis of microarrays containing a high degree of gene effects
Background: High-throughput microarrays are widely used to study gene expression across tissues and developmental stages. Analysis of gene expression data is challenging in these ...
Terri T. Ni, William J. Lemon, Yu Shyr, Tao P. Zho...
BIOINFORMATICS
2006
135views more  BIOINFORMATICS 2006»
13 years 9 months ago
Effective similarity measures for expression profiles
It is commonly accepted that genes with similar expression profiles are functionally related. However, there are many ways one can measure the similarity of expression profiles, a...
Golan Yona, William Dirks, Shafquat Rahman, David ...
BMCBI
2006
131views more  BMCBI 2006»
13 years 9 months ago
The statistics of identifying differentially expressed genes in Expresso and TM4: a comparison
Background: Analysis of DNA microarray data takes as input spot intensity measurements from scanner software and returns differential expression of genes between two conditions, t...
Allan A. Sioson, Shrinivasrao P. Mane, Pinghua Li,...
BIBM
2009
IEEE
155views Bioinformatics» more  BIBM 2009»
14 years 3 months ago
Towards Reliable Isoform Quantification Using RNA-Seq Data
Background: In eukaryotes, alternative splicing often generates multiple splice variants from a single gene. Here weexplore the use of RNA sequencing (RNA-Seq) datasets to address...
Brian E. Howard, Steffen Heber
GECCO
2000
Springer
123views Optimization» more  GECCO 2000»
14 years 16 days ago
Genomic computing: explanatory modelling for functional genomics
Many newly discovered genes are of unknown function. DNA microarrays are a method for determining the expression levels of all genes in an organism for which a complete genome seq...
Richard J. Gilbert, Jem J. Rowland, Douglas B. Kel...