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» Extracting active pathways from gene expression data
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BMCBI
2004
146views more  BMCBI 2004»
13 years 7 months ago
Defining transcriptional networks through integrative modeling of mRNA expression and transcription factor binding data
Background: Functional genomics studies are yielding information about regulatory processes in the cell at an unprecedented scale. In the yeast S. cerevisiae, DNA microarrays have...
Feng Gao, Barrett C. Foat, Harmen J. Bussemaker
BMCBI
2010
172views more  BMCBI 2010»
13 years 2 months ago
Nonparametric identification of regulatory interactions from spatial and temporal gene expression data
Background: The correlation between the expression levels of transcription factors and their target genes can be used to infer interactions within animal regulatory networks, but ...
Anil Aswani, Soile V. E. Keränen, James Brown...
PSB
2001
13 years 9 months ago
PIES, A Protein Interaction Extraction System
We consider the problem of extracting, manipulating, and managing biological pathways, especially protein-protein interaction pathways. We discuss here the Protein Interaction Ext...
Limsoon Wong
PSB
2003
13 years 9 months ago
Decomposing Gene Expression into Cellular Processes
We propose a probabilistic model for cellular processes, and an algorithm for discovering them from gene expression data. A process is associated with a set of genes that particip...
Eran Segal, Alexis Battle, Daphne Koller
GECCO
2005
Springer
156views Optimization» more  GECCO 2005»
14 years 1 months ago
Extraction of informative genes from microarray data
Identification of those genes that might anticipate the clinical behavior of different types of cancers is challenging due to availability of a smaller number of patient samples...
Topon Kumar Paul, Hitoshi Iba