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BMCBI
2010
152views more  BMCBI 2010»
13 years 7 months ago
Apples and oranges: avoiding different priors in Bayesian DNA sequence analysis
Background: One of the challenges of bioinformatics remains the recognition of short signal sequences in genomic DNA such as donor or acceptor splice sites, splicing enhancers or ...
Jens Keilwagen, Jan Grau, Stefan Posch, Ivo Grosse
BMCBI
2006
75views more  BMCBI 2006»
13 years 7 months ago
A machine learning strategy to identify candidate binding sites in human protein-coding sequence
Background: The splicing of RNA transcripts is thought to be partly promoted and regulated by sequences embedded within exons. Known sequences include binding sites for SR protein...
Thomas Down, Bernard Leong, Tim J. P. Hubbard
ISMB
2004
13 years 9 months ago
Predicting gene regulation by sigma factors in Bacillus subtilis from genome-wide data
Motivation: Sigma factors regulate the expression of genes in Bacillus subtilis at the transcriptional level. First we assess the ability of currently available gene regulatory ne...
Michiel J. L. de Hoon, Yuko Makita, Seiya Imoto, K...
RECOMB
2002
Springer
14 years 8 months ago
From promoter sequence to expression: a probabilistic framework
We present a probabilistic framework that models the process by which transcriptional binding explains the mRNA expression of different genes. Our joint probabilistic model unifie...
Eran Segal, Yoseph Barash, Itamar Simon, Nir Fried...
WABI
2010
Springer
167views Bioinformatics» more  WABI 2010»
13 years 6 months ago
Quantifying the Strength of Natural Selection of a Motif Sequence
Quantification of selective pressures on regulatory sequences is a central question in studying the evolution of gene regulatory networks. Previous methods focus primarily on sing...
Chen-Hsiang Yeang