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BMCBI
2006
124views more  BMCBI 2006»
13 years 7 months ago
Predicting transcription factor binding sites using local over-representation and comparative genomics
Background: Identifying cis-regulatory elements is crucial to understanding gene expression, which highlights the importance of the computational detection of overrepresented tran...
Matthieu Defrance, Hélène Touzet
CIBCB
2006
IEEE
14 years 1 months ago
A Systematic Computational Approach for Transcription Factor Target Gene Prediction
— Computational prediction of transcription factor’s binding sites and regulatory target genes has great value to the biological studies of cellular process. Existing practices...
Ji He, Xinbin Dai, Xuechun Zhao
CEC
2007
IEEE
13 years 11 months ago
Emergence of feedback in artificial gene regulatory networks
In this paper, we present a model for simulating the evolution of development together with a method for the analysis of emergence of negative feedback inside the regulatory networ...
Till Steiner, Lisa Schramm, Yaochu Jin, Bernhard S...
BMCBI
2008
129views more  BMCBI 2008»
13 years 7 months ago
Motif-directed network component analysis for regulatory network inference
Background: Network Component Analysis (NCA) has shown its effectiveness in discovering regulators and inferring transcription factor activities (TFAs) when both microarray data a...
Chen Wang, Jianhua Xuan, Li Chen, Po Zhao, Yue Wan...
WABI
2001
Springer
162views Bioinformatics» more  WABI 2001»
13 years 12 months ago
A Simple Hyper-Geometric Approach for Discovering Putative Transcription Factor Binding Sites
A central issue in molecular biology is understanding the regulatory mechanisms that control gene expression. The recent flood of genomic and postgenomic data opens the way for co...
Yoseph Barash, Gill Bejerano, Nir Friedman