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BMCBI
2010
150views more  BMCBI 2010»
13 years 7 months ago
Systematic calibration of a cell signaling network model
Background: Mathematical modeling is being applied to increasingly complex biological systems and datasets; however, the process of analyzing and calibrating against experimental ...
Kyoung Ae Kim, Sabrina L. Spencer, John G. Albeck,...
BMCBI
2010
105views more  BMCBI 2010»
13 years 7 months ago
A knowledge-guided strategy for improving the accuracy of scoring functions in binding affinity prediction
Background: Current scoring functions are not very successful in protein-ligand binding affinity prediction albeit their popularity in structure-based drug designs. Here, we propo...
Tiejun Cheng, Zhihai Liu, Renxiao Wang
AICOM
2006
129views more  AICOM 2006»
13 years 7 months ago
A backjumping technique for Disjunctive Logic Programming
In this work we present a backjumping technique for Disjunctive Logic Programming (DLP) under the Answer Set Semantics. It builds upon related techniques that had originally been p...
Francesco Ricca, Wolfgang Faber, Nicola Leone
BMCBI
2006
242views more  BMCBI 2006»
13 years 7 months ago
Predicting residue-wise contact orders in proteins by support vector regression
Background: The residue-wise contact order (RWCO) describes the sequence separations between the residues of interest and its contacting residues in a protein sequence. It is a ne...
Jiangning Song, Kevin Burrage
BMCBI
2006
115views more  BMCBI 2006»
13 years 7 months ago
Multivariate curve resolution of time course microarray data
Background: Modeling of gene expression data from time course experiments often involves the use of linear models such as those obtained from principal component analysis (PCA), i...
Peter D. Wentzell, Tobias K. Karakach, Sushmita Ro...