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» Finding Motifs with Gaps
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BMCBI
2008
128views more  BMCBI 2008»
13 years 7 months ago
Finding sequence motifs with Bayesian models incorporating positional information: an application to transcription factor bindin
Background: Biologically active sequence motifs often have positional preferences with respect to a genomic landmark. For example, many known transcription factor binding sites (T...
Nak-Kyeong Kim, Kannan Tharakaraman, Leonardo Mari...
ACMSE
2007
ACM
13 years 11 months ago
Finding association rules of cis-regulatory elements involved in alternative splicing
Alternative splicing (AS) is a major mechanism to generate protein diversity. A single gene might generate hundreds or even thousands of different proteins. Recently, powerful lar...
Jihye Kim, Sihui Zhao, Steffen Heber
BMCBI
2004
177views more  BMCBI 2004»
13 years 7 months ago
Gapped alignment of protein sequence motifs through Monte Carlo optimization of a hidden Markov model
Background: Certain protein families are highly conserved across distantly related organisms and belong to large and functionally diverse superfamilies. The patterns of conservati...
Andrew F. Neuwald, Jun S. Liu
BIBM
2009
IEEE
156views Bioinformatics» more  BIBM 2009»
14 years 17 days ago
Bayesian Classifier for Anchored Protein Sorting Discovery
—A typical cell has a size of only 10 µm while it contains about a billion proteins. Transportation of these proteins from their synthesis sites to their target locations within...
Fan Zhang, Jianjun Hu