The Biological General Repository for Interaction Datasets (BioGRID) database (http://www. thebiogrid.org) was developed to house and distribute collections of protein and genetic...
Bobby-Joe Breitkreutz, Chris Stark, Teresa Reguly,...
Background: Accurate estimation of statistical significance of a pairwise alignment is an important problem in sequence comparison. Recently, a comparative study of pairwise stati...
Background: In biological sequence analysis, position specific scoring matrices (PSSMs) are widely used to represent sequence motifs in nucleotide as well as amino acid sequences....
Michael Beckstette, Robert Homann, Robert Giegeric...
Background: G protein-coupled receptors (GPCRs) transduce a wide variety of extracellular signals to within the cell and therefore have a key role in regulating cell activity and ...
Catherine L. Worth, Annika Kreuchwig, Gunnar Klein...
Many applications in analytical domains often have the need to "connect the dots" i.e., query about the structure of data. In bioinformatics for example, it is typical t...