Background: Next-generation sequencing technologies allow researchers to obtain millions of sequence reads in a single experiment. One important use of the technology is the seque...
Daniel MacLean, Vincent Moulton, David J. Studholm...
Background: Bioinformatics is confronted with a new data explosion due to the availability of high throughput DNA sequencers. Data storage and analysis becomes a problem on local ...
Angela C. M. Luyf, Barbera D. C. van Schaik, Miche...
Abstract. Technological advances in experimental and computational molecular biology have revolutionized the whole fields of biology and medicine. Large-scale sequencing, expressio...
The protein-protein interaction networks of even well-studied model organisms are sketchy at best, highlighting the continued need for computational methods to help direct experim...
Background: Existing tools for multiple-sequence alignment focus on aligning protein sequence or protein-coding DNA sequence, and are often based on extensions to Needleman-Wunsch...