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ICAISC
2010
Springer
13 years 10 months ago
Computer Assisted Peptide Design and Optimization with Topology Preserving Neural Networks
Abstract. We propose a non-standard neural network called TPNN which offers the direct mapping from a peptide sequence to a property of interest in order to model the quantitative ...
Jörg D. Wichard, Sebastian Bandholtz, Carsten...
ANOR
2010
102views more  ANOR 2010»
13 years 8 months ago
Ejection chain and filter-and-fan methods in combinatorial optimization
The design of effective neighborhood structures is fundamentally important for creating better local search and metaheuristic algorithms for combinatorial optimization. Significant...
César Rego, Fred Glover
SIAMJO
2008
93views more  SIAMJO 2008»
13 years 8 months ago
Recursive Trust-Region Methods for Multiscale Nonlinear Optimization
A class of trust-region methods is presented for solving unconstrained nonlinear and possibly nonconvex discretized optimization problems, like those arising in systems governed by...
Serge Gratton, Annick Sartenaer, Philippe L. Toint
EWDW
1994
14 years 25 days ago
Optimization of Object-Oriented Queries by Inverse Methods
For object-oriented databases we propose a new technique for optimizing queries containing method invocations. This technique is based on the definition of inverse methods and que...
Johann Eder, Heinz Frank, Walter Liebhart
ESANN
2007
13 years 10 months ago
Optimizing kernel parameters by second-order methods
Radial basis function network (RBF) kernels are widely used for support vector machines (SVMs). But for model selection of an SVM, we need to optimize the kernel parameter and the ...
Shigeo Abe