As the amount of data being generated in biology has increased, a major challenge has been how to store and represent this data in a way that makes it easily accessible to researc...
Michael Backhaus, Janet Kelso, Joshua Bacher, Hein...
Background: Many newly detected point mutations are located in protein-coding regions of the human genome. Knowledge of their effects on the protein's 3D structure provides i...
Hanka Venselaar, Tim A. H. te Beek, Remko K. P. Ku...
Residue coevolution has recently emerged as an important concept, especially in the context of protein structures. While a multitude of different functions for quantifying it have...
Kevin Y. Yip, Prianka Patel, Philip M. Kim, Donald...
Background: Genome-wide expression studies have developed exponentially in recent years as a result of extensive use of microarray technology. However, expression signals are typi...
In this paper we provide a fast, data-driven solution to the failing query problem: given a query that returns an empty answer, how can one relax the query's constraints so t...