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» Functional topology in a network of protein interactions
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BMCBI
2006
122views more  BMCBI 2006»
13 years 7 months ago
A domain-oriented approach to the reduction of combinatorial complexity in signal transduction networks
Background:Receptors and scaffold proteins possess a number of distinct domains and bind multiple partners. A common problem in modeling signaling systems arises from a combinator...
Holger Conzelmann, Julio Saez-Rodriguez, Thomas Sa...
BMCBI
2004
207views more  BMCBI 2004»
13 years 7 months ago
Computational identification of transcription factor binding sites by functional analysis of sets of genes sharing overrep-resen
Background: Transcriptional regulation is a key mechanism in the functioning of the cell, and is mostly effected through transcription factors binding to specific recognition moti...
Davide Corà, Ferdinando Di Cunto, Paolo Pro...
SMI
2005
IEEE
14 years 1 months ago
Volumetric Data Analysis using Morse-Smale Complexes
The 3D Morse-Smale complex is a fundamental topological construct that partitions the domain of a real-valued function into regions having uniform gradient flow behavior. In this...
Vijay Natarajan, Valerio Pascucci
CDC
2009
IEEE
122views Control Systems» more  CDC 2009»
13 years 5 months ago
Reduced complexity models in the identification of dynamical networks: Links with sparsification problems
In many applicative scenarios it is important to derive information about the topology and the internal connections of more dynamical systems interacting together. Examples can be ...
Donatello Materassi, Giacomo Innocenti, Laura Giar...
BMCBI
2005
161views more  BMCBI 2005»
13 years 7 months ago
Non-linear mapping for exploratory data analysis in functional genomics
Background: Several supervised and unsupervised learning tools are available to classify functional genomics data. However, relatively less attention has been given to exploratory...
Francisco Azuaje, Haiying Wang, Alban Chesneau