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» Gene Expression Clustering with Functional Mixture Models
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BMCBI
2004
120views more  BMCBI 2004»
13 years 10 months ago
Optimal cDNA microarray design using expressed sequence tags for organisms with limited genomic information
Background: Expression microarrays are increasingly used to characterize environmental responses and hostparasite interactions for many different organisms. Probe selection for cD...
Yian A. Chen, David J. Mckillen, Shuyuan Wu, Matth...
GCB
2005
Springer
98views Biometrics» more  GCB 2005»
14 years 3 months ago
Composite Module Analyst: A Fitness-Based Tool for Prediction of Transcription Regulation
: Functionally related genes involved in the same molecular-genetic, biochemical, or physiological process are often regulated coordinately Such regulation is provided by precisely...
Alexander E. Kel, Tatiana Konovalova, Tagir Valeev...
UAI
2000
13 years 11 months ago
Minimum Message Length Clustering Using Gibbs Sampling
The K-Means and EM algorithms are popular in clustering and mixture modeling due to their simplicity and ease of implementation. However, they have several significant limitations...
Ian Davidson
BMCBI
2006
131views more  BMCBI 2006»
13 years 10 months ago
Hybridization interactions between probesets in short oligo microarrays lead to spurious correlations
Background: Microarrays measure the binding of nucleotide sequences to a set of sequence specific probes. This information is combined with annotation specifying the relationship ...
Michal J. Okoniewski, Crispin J. Miller
BIBM
2009
IEEE
155views Bioinformatics» more  BIBM 2009»
14 years 5 months ago
Towards Reliable Isoform Quantification Using RNA-Seq Data
Background: In eukaryotes, alternative splicing often generates multiple splice variants from a single gene. Here weexplore the use of RNA sequencing (RNA-Seq) datasets to address...
Brian E. Howard, Steffen Heber