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BMCBI
2010
116views more  BMCBI 2010»
13 years 7 months ago
Optimization algorithms for functional deimmunization of therapeutic proteins
Background: To develop protein therapeutics from exogenous sources, it is necessary to mitigate the risks of eliciting an anti-biotherapeutic immune response. A key aspect of the ...
Andrew S. Parker, Wei Zheng, Karl E. Griswold, Chr...
ISCI
2008
165views more  ISCI 2008»
13 years 7 months ago
Support vector regression from simulation data and few experimental samples
This paper considers nonlinear modeling based on a limited amount of experimental data and a simulator built from prior knowledge. The problem of how to best incorporate the data ...
Gérard Bloch, Fabien Lauer, Guillaume Colin...
SOSP
2007
ACM
14 years 4 months ago
MUVI: automatically inferring multi-variable access correlations and detecting related semantic and concurrency bugs
Software defects significantly reduce system dependability. Among various types of software bugs, semantic and concurrency bugs are two of the most difficult to detect. This pape...
Shan Lu, Soyeon Park, Chongfeng Hu, Xiao Ma, Weiha...
WWW
2005
ACM
14 years 8 months ago
A service creation environment based on end to end composition of Web services
The demand for quickly delivering new applications is increasingly becoming a business imperative today. Application development is often done in an ad hoc manner, without standar...
Vikas Agarwal, Koustuv Dasgupta, Neeran M. Karnik,...
WOSP
1998
ACM
13 years 12 months ago
Poems: end-to-end performance design of large parallel adaptive computational systems
The POEMS project is creating an environment for end-to-end performance modeling of complex parallel and distributed systems, spanning the domains of application software, runti...
Ewa Deelman, Aditya Dube, Adolfy Hoisie, Yong Luo,...