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» Genomic characterization of perturbation sensitivity
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BMCBI
2010
96views more  BMCBI 2010»
13 years 8 months ago
ModuleOrganizer: detecting modules in families of transposable elements
Background: Most known eukaryotic genomes contain mobile copied elements called transposable elements. In some species, these elements account for the majority of the genome seque...
Sébastien Tempel, Christine Rousseau, Fariz...
STOC
2004
ACM
150views Algorithms» more  STOC 2004»
14 years 8 months ago
Typical properties of winners and losers in discrete optimization
We present a probabilistic analysis for a large class of combinatorial optimization problems containing, e.g., all binary optimization problems defined by linear constraints and a...
René Beier, Berthold Vöcking
BMCBI
2010
179views more  BMCBI 2010»
13 years 8 months ago
A semi-supervised learning approach to predict synthetic genetic interactions by combining functional and topological properties
Background: Genetic interaction profiles are highly informative and helpful for understanding the functional linkages between genes, and therefore have been extensively exploited ...
Zhuhong You, Zheng Yin, Kyungsook Han, De-Shuang H...
CCE
2011
13 years 3 months ago
Computational energy-based redesign of robust proteins
The robustness of a system is a property that pervades all aspects of Nature. The ability of a system to adapt itself to perturbations due to internal and external agents, to agin...
Giovanni Stracquadanio, Giuseppe Nicosia
DAC
2007
ACM
14 years 9 months ago
Synthesizing Stochasticity in Biochemical Systems
Randomness is inherent to biochemistry: at each instant, the sequence of reactions that fires is a matter of chance. Some biological systems exploit such randomness, choosing betw...
Brian Fett, Jehoshua Bruck, Marc D. Riedel