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ISMB
1997
13 years 10 months ago
Identifying Chimerism in Proteins Using Hidden Markov Models of Codon Usage
Protein chimerism is a phenomenon involving the combination of multiple ancestral sequences into a single, multi-domain protein through evolution. We propose a novel method for de...
Lawrence Hunter, Barry Zeeberg
BMCBI
2004
126views more  BMCBI 2004»
13 years 8 months ago
A probabilistic model for the evolution of RNA structure
Background: For the purposes of finding and aligning noncoding RNA gene- and cis-regulatory elements in multiple-genome datasets, it is useful to be able to derive multi-sequence ...
Ian Holmes
JCSS
2008
80views more  JCSS 2008»
13 years 8 months ago
Improved bounds on sorting by length-weighted reversals
We study the problem of sorting binary sequences and permutations by length-weighted reversals. We consider a wide class of cost functions, namely f( ) = for all 0, where is the...
Michael A. Bender, Dongdong Ge, Simai He, Haodong ...
BMCBI
2010
87views more  BMCBI 2010»
13 years 8 months ago
Epigenetic domains found in mouse embryonic stem cells via a hidden Markov model
Background: Epigenetics is an important layer of transcriptional control necessary for cell-type specific gene regulation. Recent studies have shown significant epigenetic pattern...
Jessica L. Larson, Guo-Cheng Yuan
COCOON
2005
Springer
14 years 2 months ago
Perfect Sorting by Reversals
In computational biology, gene order data is often modelled as signed permutations. A classical problem in genome comparison is to detect conserved segments in a permutation, that ...
Marie-France Sagot, Eric Tannier