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    BMCBI
    2008
    107views more  BMCBI 2008»
    Multi-agent systems in epidemiology: a first step for computational biology in the study of vector-borne disease transmission
    13 years 8 months ago
    Multi-agent systems in epidemiology: a first step for computational biology in the study of vector-borne disease transmission
    Download  www.biomedcentral.com
    Background: Computational biology is often associated with genetic or genomic studies only. However, thanks to the increase of computational resources, computational models are ap...
    Benjamin Roche, Jean-François Guégan...
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    SAC
    2011
    ACM
    244views Applied Computing» more  SAC 2011»
    A quasi-Newton acceleration for high-dimensional optimization algorithms
    13 years 3 months ago
    A quasi-Newton acceleration for high-dimensional optimization algorithms
    Download  dalexander.bol.ucla.edu
    Abstract In many statistical problems, maximum likelihood estimation by an EM or MM algorithm suffers from excruciatingly slow convergence. This tendency limits the application of ...
    Hua Zhou, David Alexander, Kenneth Lange
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    BMCBI
    2008
    149views more  BMCBI 2008»
    Evolution of biological sequences implies an extreme value distribution of type I for both global and local pairwise alignment s
    13 years 8 months ago
    Evolution of biological sequences implies an extreme value distribution of type I for both global and local pairwise alignment s
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    Background: Confidence in pairwise alignments of biological sequences, obtained by various methods such as Blast or Smith-Waterman, is critical for automatic analyses of genomic d...
    Olivier Bastien, Eric Maréchal
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    BMCBI
    2008
    117views more  BMCBI 2008»
    A probabilistic framework to predict protein function from interaction data integrated with semantic knowledge
    13 years 8 months ago
    A probabilistic framework to predict protein function from interaction data integrated with semantic knowledge
    Download  www.biomedcentral.com
    Background: The functional characterization of newly discovered proteins has been a challenge in the post-genomic era. Protein-protein interactions provide insights into the funct...
    Young-Rae Cho, Lei Shi, Murali Ramanathan, Aidong ...
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    BMCBI
    2010
    136views more  BMCBI 2010»
    Protein structure analysis of mutations causing inheritable diseases. An e-Science approach with life scientist friendly interfa
    13 years 8 months ago
    Protein structure analysis of mutations causing inheritable diseases. An e-Science approach with life scientist friendly interfa
    Download  www.biomedcentral.com
    Background: Many newly detected point mutations are located in protein-coding regions of the human genome. Knowledge of their effects on the protein's 3D structure provides i...
    Hanka Venselaar, Tim A. H. te Beek, Remko K. P. Ku...
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