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» Goal-oriented Analysis of Regulations
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HYBRID
2004
Springer
15 years 9 months ago
Modeling Subtilin Production in Bacillus subtilis Using Stochastic Hybrid Systems
The genetic network regulating the biosynthesis of subtilin in Bacillus subtilis is modeled as a stochastic hybrid system. The continuous state of the hybrid system is the concentr...
Jianghai Hu, Wei Chung Wu, Shankar Sastry
BIOINFORMATICS
2007
195views more  BIOINFORMATICS 2007»
15 years 4 months ago
Context-dependent clustering for dynamic cellular state modeling of microarray gene expression
Motivation: High-throughput expression profiling allows researchers to study gene activities globally. Genes with similar expression profiles are likely to encode proteins that ma...
Shinsheng Yuan, Ker-Chau Li
150
Voted
BMCBI
2008
169views more  BMCBI 2008»
15 years 4 months ago
CompMoby: Comparative MobyDick for detection of cis-regulatory motifs
Background: The regulation of gene expression is complex and occurs at many levels, including transcriptional and post-transcriptional, in metazoans. Transcriptional regulation is...
Christina Chaivorapol, Collin Melton, Grace Wei, R...
146
Voted
BMCBI
2008
118views more  BMCBI 2008»
15 years 4 months ago
Evaluation of phylogenetic footprint discovery for predicting bacterial cis-regulatory elements and revealing their evolution
Background: The detection of conserved motifs in promoters of orthologous genes (phylogenetic footprints) has become a common strategy to predict cis-acting regulatory elements. S...
Rekin's Janky, Jacques van Helden
147
Voted
BMCBI
2006
137views more  BMCBI 2006»
15 years 4 months ago
A classification-based framework for predicting and analyzing gene regulatory response
Background: We have recently introduced a predictive framework for studying gene transcriptional regulation in simpler organisms using a novel supervised learning algorithm called...
Anshul Kundaje, Manuel Middendorf, Mihir Shah, Chr...