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» Hardness Results for Homology Localization
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RECOMB
2004
Springer
14 years 7 months ago
Multiple Genome Alignment by Clustering Pairwise Matches
We have developed a multiple genome alignment algorithm by using a sequence clustering algorithm to combine local pairwise genome sequence matches produced by pairwise genome align...
Jeong-Hyeon Choi, Kwangmin Choi, Hwan-Gue Cho, Sun...
BIBM
2008
IEEE
113views Bioinformatics» more  BIBM 2008»
14 years 1 months ago
Towards Site-Based Protein Functional Annotations
Abstract—The exact relationship between protein active centers and protein functions is unclear even after decades of intensive study. To improve the functional prediction abilit...
Seak Fei Lei, Jun Huan
BMCBI
2004
94views more  BMCBI 2004»
13 years 7 months ago
The MB2 gene family of Plasmodium species has a unique combination of S1 and GTP-binding domains
Background: Identification and characterization of novel Plasmodium gene families is necessary for developing new anti-malarial therapeutics. The products of the Plasmodium falcip...
Lisa C. Romero, Thanh Vinh Nguyen, Benoit Deville,...
BMCBI
2010
116views more  BMCBI 2010»
13 years 7 months ago
A hybrid approach to protein folding problem integrating constraint programming with local search
Background: The protein folding problem remains one of the most challenging open problems in computational biology. Simplified models in terms of lattice structure and energy func...
Abu Zafer M. Dayem Ullah, Kathleen Steinhöfel
AAAI
1994
13 years 8 months ago
Noise Strategies for Improving Local Search
It has recently been shown that local search is surprisingly good at nding satisfying assignments for certain computationally hard classes of CNF formulas. The performance of basi...
Bart Selman, Henry A. Kautz, Bram Cohen