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BMCBI
2010
104views more  BMCBI 2010»
13 years 9 months ago
A novel chemogenomics analysis of G protein-coupled receptors (GPCRs) and their ligands: a potential strategy for receptor de-or
Background: G protein-coupled receptors (GPCRs) represent a family of well-characterized drug targets with significant therapeutic value. Phylogenetic classifications may help to ...
Eelke van der Horst, Julio E. Peironcely, Adriaan ...
BMCBI
2008
158views more  BMCBI 2008»
13 years 9 months ago
Analyzing M-CSF dependent monocyte/macrophage differentiation: Expression modes and meta-modes derived from an independent compo
Background: The analysis of high-throughput gene expression data sets derived from microarray experiments still is a field of extensive investigation. Although new approaches and ...
Dominik Lutter, Peter Ugocsai, Margot Grandl, Evel...
BMCBI
2008
200views more  BMCBI 2008»
13 years 9 months ago
Defining functional distances over Gene Ontology
Background: A fundamental problem when trying to define the functional relationships between proteins is the difficulty in quantifying functional similarities, even when well-stru...
Angela del Pozo, Florencio Pazos, Alfonso Valencia
BMCBI
2008
154views more  BMCBI 2008»
13 years 9 months ago
Bayesian models and meta analysis for multiple tissue gene expression data following corticosteroid administration
Background: This paper addresses key biological problems and statistical issues in the analysis of large gene expression data sets that describe systemic temporal response cascade...
Yulan Liang, Arpad Kelemen
BMCBI
2007
149views more  BMCBI 2007»
13 years 9 months ago
Novel and simple transformation algorithm for combining microarray data sets
Background: With microarray technology, variability in experimental environments such as RNA sources, microarray production, or the use of different platforms, can cause bias. Suc...
Ki-Yeol Kim, Dong Hyuk Ki, Ha Jin Jeong, Hei-Cheul...