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BMCBI
2008
95views more  BMCBI 2008»
13 years 8 months ago
Mining protein networks for synthetic genetic interactions
Background: The local connectivity and global position of a protein in a protein interaction network are known to correlate with some of its functional properties, including its e...
Sri R. Paladugu, Shan Zhao, Animesh Ray, Alpan Rav...
BMCBI
2008
142views more  BMCBI 2008»
13 years 8 months ago
Microarray data mining: A novel optimization-based approach to uncover biologically coherent structures
Background: DNA microarray technology allows for the measurement of genome-wide expression patterns. Within the resultant mass of data lies the problem of analyzing and presenting...
Meng Piao Tan, Erin N. Smith, James R. Broach, Chr...
BMCBI
2008
172views more  BMCBI 2008»
13 years 8 months ago
Compo: composite motif discovery using discrete models
Background: Computational discovery of motifs in biomolecular sequences is an established field, with applications both in the discovery of functional sites in proteins and regula...
Geir Kjetil Sandve, Osman Abul, Finn Drablø...
BMCBI
2008
123views more  BMCBI 2008»
13 years 8 months ago
Validation of protein models by a neural network approach
Background: The development and improvement of reliable computational methods designed to evaluate the quality of protein models is relevant in the context of protein structure re...
Paolo Mereghetti, Maria Luisa Ganadu, Elena Papale...
BMCBI
2008
119views more  BMCBI 2008»
13 years 8 months ago
A new method for 2D gel spot alignment: application to the analysis of large sample sets in clinical proteomics
Background: In current comparative proteomics studies, the large number of images generated by 2D gels is currently compared using spot matching algorithms. Unfortunately, differe...
Sabine Pérès, Laurence Molina, Nicol...
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