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RECOMB
2010
Springer
13 years 10 months ago
Subnetwork State Functions Define Dysregulated Subnetworks in Cancer
Abstract. Emerging research demonstrates the potential of proteinprotein interaction (PPI) networks in uncovering the mechanistic bases of cancers, through identification of intera...
Salim A. Chowdhury, Rod K. Nibbe, Mark R. Chance, ...
BIBE
2006
IEEE
112views Bioinformatics» more  BIBE 2006»
14 years 2 months ago
Finding Correlations in Functionally Equivalent Proteins by Integrating Automated and Visual Data Exploration
The analysis of alignments of functionally equivalent proteins can reveal regularities such as correlated positions or residue patterns which are important to ensure a specific f...
Daniel A. Keim, Daniela Oelke, Royal Truman, Klaus...
BMCBI
2005
97views more  BMCBI 2005»
13 years 8 months ago
Sequence variation in ligand binding sites in proteins
Background: The recent explosion in the availability of complete genome sequences has led to the cataloging of tens of thousands of new proteins and putative proteins. Many of the...
Thomas J. Magliery, Lynne Regan
ICML
2008
IEEE
14 years 9 months ago
Detecting statistical interactions with additive groves of trees
Discovering additive structure is an important step towards understanding a complex multi-dimensional function because it allows the function to be expressed as the sum of lower-d...
Daria Sorokina, Rich Caruana, Mirek Riedewald, Dan...
BMCBI
2005
119views more  BMCBI 2005»
13 years 8 months ago
A protein domain interaction interface database: InterPare
Background: Most proteins function by interacting with other molecules. Their interaction interfaces are highly conserved throughout evolution to avoid undesirable interactions th...
Sungsam Gong, Changbum Park, Hansol Choi, Junsu Ko...