The protein-protein interaction networks of even well-studied model organisms are sketchy at best, highlighting the continued need for computational methods to help direct experim...
Background: The PD-(D/E)XK nuclease superfamily, initially identified in type II restriction endonucleases and later in many enzymes involved in DNA recombination and repair, is o...
Modeling dynamical systems composed of aggregations of primitive proteins is critical to the field of astrobiological science, which studies early evolutionary structures dealing ...
Motivation: High-throughput expression profiling allows researchers to study gene activities globally. Genes with similar expression profiles are likely to encode proteins that ma...
Background: A number of methods that use both protein structural and evolutionary information are available to predict the functional consequences of missense mutations. However, ...
Chris J. Needham, James R. Bradford, Andrew J. Bul...