Background: Designing small-molecule kinase inhibitors with desirable selectivity profiles is a major challenge in drug discovery. A high-throughput screen for inhibitors of a giv...
Daniel R. Caffrey, Elizabeth A. Lunney, Deborah J....
Background: Identification of approximate tandem repeats is an important task of broad significance and still remains a challenging problem of computational genomics. Often there ...
Vladimir Paar, Nenad Pavin, Ivan Basar, Marija Ros...
Background: In recent years, substantial effort has been applied to de novo regulatory motif discovery. At this time, more than 150 software tools exist to detect regulatory bindi...
Daniel Quest, Kathryn Dempsey, Mohammad Shafiullah...
Background: Biochemically detailed stoichiometric matrices have now been reconstructed for various bacteria, yeast, and for the human cardiac mitochondrion based on genomic and pr...
Scott A. Becker, Nathan D. Price, Bernhard O. Pals...
Background: Most virus detection methods are geared towards the detection of specific single viruses or just a few known targets, and lack the capability to uncover the novel viru...