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BMCBI
2008
170views more  BMCBI 2008»
13 years 9 months ago
A genetic approach for building different alphabets for peptide and protein classification
Background: In this paper, it is proposed an optimization approach for producing reduced alphabets for peptide classification, using a Genetic Algorithm. The classification task i...
Loris Nanni, Alessandra Lumini
BMCBI
2008
114views more  BMCBI 2008»
13 years 9 months ago
Testing the Coulomb/Accessible Surface Area solvent model for protein stability, ligand binding, and protein design
Background: Protein structure prediction and computational protein design require efficient yet sufficiently accurate descriptions of aqueous solvent. We continue to evaluate the ...
Marcel Schmidt am Busch, Anne Lopes, Najette Amara...
BMCBI
2008
139views more  BMCBI 2008»
13 years 9 months ago
Hierarchical structure of cascade of primary and secondary periodicities in Fourier power spectrum of alphoid higher order repea
Background: Identification of approximate tandem repeats is an important task of broad significance and still remains a challenging problem of computational genomics. Often there ...
Vladimir Paar, Nenad Pavin, Ivan Basar, Marija Ros...
BMCBI
2008
135views more  BMCBI 2008»
13 years 9 months ago
Fregene: Simulation of realistic sequence-level data in populations and ascertained samples
Background: FREGENE simulates sequence-level data over large genomic regions in large populations. Because, unlike coalescent simulators, it works forwards through time, it allows...
Marc Chadeau-Hyam, Clive J. Hoggart, Paul F. O'Rei...
BMCBI
2008
167views more  BMCBI 2008»
13 years 9 months ago
Expression profiles of switch-like genes accurately classify tissue and infectious disease phenotypes in model-based classificat
Background: Large-scale compilation of gene expression microarray datasets across diverse biological phenotypes provided a means of gathering a priori knowledge in the form of ide...
Michael Gormley, Aydin Tozeren