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» Identifying Structural Motifs in Proteins
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BMCBI
2010
109views more  BMCBI 2010»
13 years 10 months ago
Pripper: prediction of caspase cleavage sites from whole proteomes
Background: Caspases are a family of proteases that have central functions in programmed cell death (apoptosis) and inflammation. Caspases mediate their effects through aspartate-...
Mirva Piippo, Niina Lietzén, Olli Nevalaine...
BMCBI
2010
167views more  BMCBI 2010»
13 years 10 months ago
Creating PWMs of transcription factors using 3D structure-based computation of protein-DNA free binding energies
Background: Knowledge of transcription factor-DNA binding patterns is crucial for understanding gene transcription. Numerous DNA-binding proteins are annotated as transcription fa...
Denitsa Alamanova, Philip Stegmaier, Alexander E. ...
CIBCB
2009
IEEE
13 years 11 months ago
Improved prediction of trans-membrane spans in proteins using an artificial neural network
Tools for the identification of trans-membrane spans from the protein sequence are widely used in the experimental community. Computational structural biology seeks to increase the...
Julia Koehler, Ralf Mueller, Jens Meiler
BMCBI
2005
127views more  BMCBI 2005»
13 years 9 months ago
Genomes are covered with ubiquitous 11 bp periodic patterns, the "class A flexible patterns"
Background: The genomes of prokaryotes and lower eukaryotes display a very strong 11 bp periodic bias in the distribution of their nucleotides. This bias is present throughout a g...
Etienne Larsabal, Antoine Danchin
BMCBI
2006
102views more  BMCBI 2006»
13 years 10 months ago
MycoperonDB: a database of computationally identified operons and transcriptional units in Mycobacteria
Background: A key post genomics challenge is to identify how genes in an organism come together and perform physiological functions. An important first step in this direction is t...
Sarita Ranjan, Ranjit Kumar Gundu, Akash Ranjan