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BMCBI
2010
109views more  BMCBI 2010»
15 years 4 months ago
Prediction of the binding affinities of peptides to class II MHC using a regularized thermodynamic model
Background: The binding of peptide fragments of extracellular peptides to class II MHC is a crucial event in the adaptive immune response. Each MHC allotype generally binds a dist...
Andrew J. Bordner, Hans D. Mittelmann
BMCBI
2010
103views more  BMCBI 2010»
15 years 4 months ago
Predicting the protein-protein interactions using primary structures with predicted protein surface
Background: Many biological functions involve various protein-protein interactions (PPIs). Elucidating such interactions is crucial for understanding general principles of cellula...
Darby Tien-Hao Chang, Yu-Tang Syu, Po-Chang Lin
BMCBI
2010
106views more  BMCBI 2010»
15 years 4 months ago
A novel approach for haplotype-based association analysis using family data
Background: Haplotype-based approaches have been extensively studied for case-control association mapping in recent years. It has been shown that haplotype methods can provide mor...
Yixuan Chen, Xin Li, Jing Li
BMCBI
2008
109views more  BMCBI 2008»
15 years 4 months ago
MetaFIND: A feature analysis tool for metabolomics data
Background: Metabolomics, or metabonomics, refers to the quantitative analysis of all metabolites present within a biological sample and is generally carried out using NMR spectro...
Kenneth Bryan, Lorraine Brennan, Padraig Cunningha...
BMCBI
2010
159views more  BMCBI 2010»
15 years 4 months ago
Predicting domain-domain interaction based on domain profiles with feature selection and support vector machines
Background: Protein-protein interaction (PPI) plays essential roles in cellular functions. The cost, time and other limitations associated with the current experimental methods ha...
Alvaro J. González, Li Liao
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