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BMCBI
2005
118views more  BMCBI 2005»
13 years 10 months ago
Variation in structural location and amino acid conservation of functional sites in protein domain families
Background: The functional sites of a protein present important information for determining its cellular function and are fundamental in drug design. Accordingly, accurate methods...
Birgit Pils, Richard R. Copley, Jörg Schultz
BMCBI
2005
169views more  BMCBI 2005»
13 years 10 months ago
An adaptive method for cDNA microarray normalization
Background: Normalization is a critical step in analysis of gene expression profiles. For duallabeled arrays, global normalization assumes that the majority of the genes on the ar...
Yingdong Zhao, Ming-Chung Li, Richard Simon
BMCBI
2005
102views more  BMCBI 2005»
13 years 10 months ago
BioCreAtIvE Task1A: entity identification with a stochastic tagger
Background: Our approach to Task 1A was inspired by Tanabe and Wilbur's ABGene system [1,2]. Like Tanabe and Wilbur, we approached the problem as one of part-of-speech taggin...
Shuhei Kinoshita, K. Bretonnel Cohen, Philip V. Og...
BMCBI
2005
112views more  BMCBI 2005»
13 years 10 months ago
Web services and workflow management for biological resources
Backgorund: The completion of the Human Genome Project has resulted in large quantities of biological data which are proving difficult to manage and integrate effectively. There i...
Paolo Romano 0001, Domenico Marra, Luciano Milanes...
TMI
2008
149views more  TMI 2008»
13 years 10 months ago
Shape-Driven Three-Dimensional Watersnake Segmentation of Biological Membranes in Electron Tomography
Abstract--Due to the significant complexity of membrane morphology and the generally poor image quality in electron tomographic volumes, current automatic methods for segmentation ...
Hieu Tat Nguyen, Qiang Ji
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