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BMCBI
2010
150views more  BMCBI 2010»
13 years 10 months ago
Systematic calibration of a cell signaling network model
Background: Mathematical modeling is being applied to increasingly complex biological systems and datasets; however, the process of analyzing and calibrating against experimental ...
Kyoung Ae Kim, Sabrina L. Spencer, John G. Albeck,...
BMCBI
2010
89views more  BMCBI 2010»
13 years 10 months ago
Enhancing metabolomic data analysis with Progressive Consensus Alignment of NMR Spectra (PCANS)
Background: Nuclear magnetic resonance spectroscopy is one of the primary tools in metabolomics analyses, where it is used to track and quantify changes in metabolite concentratio...
Jennifer M. Staab, Thomas M. O'Connell, Shawn M. G...
BMCBI
2010
147views more  BMCBI 2010»
13 years 10 months ago
Automatic detection of anchor points for multiple sequence alignment
Background: Determining beforehand specific positions to align (anchor points) has proved valuable for the accuracy of automated multiple sequence alignment (MSA) software. This f...
Florian Pitschi, Claudine Devauchelle, Eduardo Cor...
BMCBI
2010
146views more  BMCBI 2010»
13 years 10 months ago
On the Choice and Number of Microarrays for Transcriptional Regulatory Network Inference
Background: Transcriptional regulatory network inference (TRNI) from large compendia of DNA microarrays has become a fundamental approach for discovering transcription factor (TF)...
Elissa J. Cosgrove, Timothy S. Gardner, Eric D. Ko...
BMCBI
2010
91views more  BMCBI 2010»
13 years 10 months ago
Ranked retrieval of Computational Biology models
Background: The study of biological systems demands computational support. If targeting a biological problem, the reuse of existing computational models can save time and effort. ...
Ron Henkel, Lukas Endler, Andre Peters, Nicolas Le...