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BMCBI
2010
163views more  BMCBI 2010»
13 years 7 months ago
Reduced representation of protein structure: implications on efficiency and scope of detection of structural similarity
Background: Computational comparison of two protein structures is the starting point of many methods that build on existing knowledge, such as structure modeling (including modeli...
Zong Hong Zhang, Hwee Kuan Lee, Ivana Mihalek
BMCBI
2004
158views more  BMCBI 2004»
13 years 7 months ago
Improvement of alignment accuracy utilizing sequentially conserved motifs
Background: Multiple sequence alignment algorithms are very important tools in molecular biology today. Accurate alignment of proteins is central to several areas such as homology...
Saikat Chakrabarti, Nitin Bhardwaj, Prem A. Anand,...
BMCBI
2006
130views more  BMCBI 2006»
13 years 7 months ago
4SALE - A tool for synchronous RNA sequence and secondary structure alignment and editing
Background: In sequence analysis the multiple alignment builds the fundament of all proceeding analyses. Errors in an alignment could strongly influence all succeeding analyses an...
Philipp N. Seibel, Tobias Müller, Thomas Dand...
BMCBI
2008
109views more  BMCBI 2008»
13 years 7 months ago
ConStruct: Improved construction of RNA consensus structures
Background: Aligning homologous non-coding RNAs (ncRNAs) correctly in terms of sequence and structure is an unresolved problem, due to both mathematical complexity and imperfect s...
Andreas Wilm, Kornelia Linnenbrink, Gerhard Steger
BMCBI
2006
139views more  BMCBI 2006»
13 years 7 months ago
Improvement in accuracy of multiple sequence alignment using novel group-to-group sequence alignment algorithm with piecewise li
Background: Multiple sequence alignment (MSA) is a useful tool in bioinformatics. Although many MSA algorithms have been developed, there is still room for improvement in accuracy...
Shinsuke Yamada, Osamu Gotoh, Hayato Yamana