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» Incremental Kernel Machines for Protein Remote Homology Dete...
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BMCBI
2008
138views more  BMCBI 2008»
13 years 7 months ago
Application of nonnegative matrix factorization to improve profile-profile alignment features for fold recognition and remote ho
Background: Nonnegative matrix factorization (NMF) is a feature extraction method that has the property of intuitive part-based representation of the original features. This uniqu...
Inkyung Jung, Jaehyung Lee, Soo-Young Lee, Dongsup...
BMCBI
2006
180views more  BMCBI 2006»
13 years 7 months ago
Building multiclass classifiers for remote homology detection and fold recognition
Motivation Protein remote homology prediction and fold recognition are central problems in computational biology. Supervised learning algorithms based on support vector machines a...
Huzefa Rangwala, George Karypis
BMCBI
2010
101views more  BMCBI 2010»
13 years 7 months ago
Hidden Markov model speed heuristic and iterative HMM search procedure
Background: Profile hidden Markov models (profile-HMMs) are sensitive tools for remote protein homology detection, but the main scoring algorithms, Viterbi or Forward, require con...
L. Steven Johnson, Sean R. Eddy, Elon Portugaly
BMCBI
2008
143views more  BMCBI 2008»
13 years 7 months ago
Gene identification and protein classification in microbial metagenomic sequence data via incremental clustering
Background: The identification and study of proteins from metagenomic datasets can shed light on the roles and interactions of the source organisms in their communities. However, ...
Shibu Yooseph, Weizhong Li, Granger G. Sutton
BIBM
2008
IEEE
125views Bioinformatics» more  BIBM 2008»
13 years 9 months ago
On the Role of Local Matching for Efficient Semi-supervised Protein Sequence Classification
Recent studies in protein sequence analysis have leveraged the power of unlabeled data. For example, the profile and mismatch neighborhood kernels have shown significant improveme...
Pavel P. Kuksa, Pai-Hsi Huang, Vladimir Pavlovic