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» Inferring differentiation pathways from gene expression
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JAMIA
2011
94views more  JAMIA 2011»
12 years 11 months ago
Protein-network modeling of prostate cancer gene signatures reveals essential pathways in disease recurrence
Objective Uncovering the dominant molecular deregulation among the multitude of pathways implicated in aggressive prostate cancer is essential to intelligently developing targeted...
James L. Chen, Jianrong Li, Walter M. Stadler, Yve...
BMCBI
2010
96views more  BMCBI 2010»
13 years 9 months ago
A statistical framework for differential network analysis from microarray data
Background: It has been long well known that genes do not act alone; rather groups of genes act in consort during a biological process. Consequently, the expression levels of gene...
Ryan Gill, Somnath Datta, Susmita Datta
BMCBI
2006
86views more  BMCBI 2006»
13 years 8 months ago
The impact of sample imbalance on identifying differentially expressed genes
Background: Recently several statistical methods have been proposed to identify genes with differential expression between two conditions. However, very few studies consider the p...
Kun Yang, Jianzhong Li, Hong Gao
BIB
2008
75views more  BIB 2008»
13 years 9 months ago
Gene-set approach for expression pattern analysis
Recently developed gene set analysis methods evaluate differential expression patterns of gene groups instead of those of individual genes. This approach especially targets gene g...
Dougu Nam, Seon-Young Kim
ISBRA
2009
Springer
14 years 3 months ago
Practical Quality Assessment of Microarray Data by Simulation of Differential Gene Expression
There are many methods for assessing the quality of microarray data, but little guidance regarding what to do when defective data is identified. Depending on the scientific questio...
Brian E. Howard, Beate Sick, Steffen Heber