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BMCBI
2008
84views more  BMCBI 2008»
13 years 10 months ago
Prediction of specificity-determining residues for small-molecule kinase inhibitors
Background: Designing small-molecule kinase inhibitors with desirable selectivity profiles is a major challenge in drug discovery. A high-throughput screen for inhibitors of a giv...
Daniel R. Caffrey, Elizabeth A. Lunney, Deborah J....
BMCBI
2006
145views more  BMCBI 2006»
13 years 9 months ago
GEM System: automatic prototyping of cell-wide metabolic pathway models from genomes
Background: Successful realization of a "systems biology" approach to analyzing cells is a grand challenge for our understanding of life. However, current modeling appro...
Kazuharu Arakawa, Yohei Yamada, Kosaku Shinoda, Yo...
TCBB
2008
137views more  TCBB 2008»
13 years 9 months ago
Toward Verified Biological Models
The last several decades have witnessed a vast accumulation of biological data and data analysis. Many of these data sets represent only a small fraction of the system's behav...
Avital Sadot, Jasmin Fisher, Dan Barak, Yishai Adm...
JSS
2008
122views more  JSS 2008»
13 years 8 months ago
Traffic-aware stress testing of distributed real-time systems based on UML models using genetic algorithms
This report presents a model-driven, stress test methodology aimed at increasing chances of discovering faults related to network traffic in Distributed Real-Time Systems (DRTS). T...
Vahid Garousi, Lionel C. Briand, Yvan Labiche
CGF
2011
13 years 1 months ago
Visual Exploration of Time-Series Data with Shape Space Projections
Time-series data is a common target for visual analytics, as they appear in a wide range of application domains. Typical tasks in analyzing time-series data include identifying cy...
Matthew O. Ward, Zhenyu Guo