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BMCBI
2010
153views more  BMCBI 2010»
13 years 7 months ago
Metamotifs - a generative model for building families of nucleotide position weight matrices
Background: Development of high-throughput methods for measuring DNA interactions of transcription factors together with computational advances in short motif inference algorithms...
Matias Piipari, Thomas A. Down, Tim J. P. Hubbard
BMCBI
2011
12 years 11 months ago
Reconstructing genome-wide regulatory network of E. coli using transcriptome data and predicted transcription factor activities
Background: Gene regulatory networks play essential roles in living organisms to control growth, keep internal metabolism running and respond to external environmental changes. Un...
Yao Fu, Laura R. Jarboe, Julie A. Dickerson
BMCBI
2010
123views more  BMCBI 2010»
13 years 2 months ago
Predicting conserved protein motifs with Sub-HMMs
Background: Profile HMMs (hidden Markov models) provide effective methods for modeling the conserved regions of protein families. A limitation of the resulting domain models is th...
Kevin Horan, Christian R. Shelton, Thomas Girke
BMCBI
2006
137views more  BMCBI 2006»
13 years 7 months ago
A classification-based framework for predicting and analyzing gene regulatory response
Background: We have recently introduced a predictive framework for studying gene transcriptional regulation in simpler organisms using a novel supervised learning algorithm called...
Anshul Kundaje, Manuel Middendorf, Mihir Shah, Chr...
BMCBI
2010
150views more  BMCBI 2010»
13 years 7 months ago
AMS 3.0: prediction of post-translational modifications
Background: We present here the recent update of AMS algorithm for identification of post-translational modification (PTM) sites in proteins based only on sequence information, us...
Subhadip Basu, Dariusz Plewczynski