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» Integration Workbench: Integrating Schema Integration Tools
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BMCBI
2006
121views more  BMCBI 2006»
13 years 7 months ago
Evaluation of sequence alignments and oligonucleotide probes with respect to three-dimensional structure of ribosomal RNA using
Background: Availability of high-resolution RNA crystal structures for the 30S and 50S ribosomal subunits and the subsequent validation of comparative secondary structure models h...
Yadhu Kumar, Ralf Westram, Peter Kipfer, Harald Me...
BMCBI
2006
179views more  BMCBI 2006»
13 years 7 months ago
Multiscale Hy3S: Hybrid stochastic simulation for supercomputers
Background: Stochastic simulation has become a useful tool to both study natural biological systems and design new synthetic ones. By capturing the intrinsic molecular fluctuation...
Howard Salis, Vassilios Sotiropoulos, Yiannis N. K...
BMCBI
2006
131views more  BMCBI 2006»
13 years 7 months ago
The statistics of identifying differentially expressed genes in Expresso and TM4: a comparison
Background: Analysis of DNA microarray data takes as input spot intensity measurements from scanner software and returns differential expression of genes between two conditions, t...
Allan A. Sioson, Shrinivasrao P. Mane, Pinghua Li,...
BMCBI
2006
160views more  BMCBI 2006»
13 years 7 months ago
Gene prediction in eukaryotes with a generalized hidden Markov model that uses hints from external sources
Background: In order to improve gene prediction, extrinsic evidence on the gene structure can be collected from various sources of information such as genome-genome comparisons an...
Mario Stanke, Oliver Schöffmann, Burkhard Mor...
BMCBI
2006
156views more  BMCBI 2006»
13 years 7 months ago
Score-based prediction of genomic islands in prokaryotic genomes using hidden Markov models
Background: Horizontal gene transfer (HGT) is considered a strong evolutionary force shaping the content of microbial genomes in a substantial manner. It is the difference in spee...
Stephan Waack, Oliver Keller, Roman Asper, Thomas ...