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» Kernel Based Functional Gene Grouping
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BMCBI
2010
154views more  BMCBI 2010»
13 years 11 months ago
Candidate gene prioritization by network analysis of differential expression using machine learning approaches
Background: Discovering novel disease genes is still challenging for diseases for which no prior knowledge - such as known disease genes or disease-related pathways - is available...
Daniela Nitsch, Joana P. Gonçalves, Fabian ...
BMCBI
2008
126views more  BMCBI 2008»
13 years 11 months ago
Relating gene expression data on two-component systems to functional annotations in Escherichia coli
Background: Obtaining physiological insights from microarray experiments requires computational techniques that relate gene expression data to functional information. Traditionall...
Anne M. Denton, Jianfei Wu, Megan K. Townsend, Pre...
ICDM
2005
IEEE
215views Data Mining» more  ICDM 2005»
14 years 4 months ago
CLUGO: A Clustering Algorithm for Automated Functional Annotations Based on Gene Ontology
We address the issue of providing highly informative and comprehensive annotations using information revealed by the structured vocabularies of Gene Ontology (GO). For a target, a...
In-Yee Lee, Jan-Ming Ho, Ming-Syan Chen
BMCBI
2010
135views more  BMCBI 2010»
13 years 11 months ago
Detecting disease associated modules and prioritizing active genes based on high throughput data
Background: The accumulation of high-throughput data greatly promotes computational investigation of gene function in the context of complex biological systems. However, a biologi...
Yu-Qing Qiu, Shi-Hua Zhang, Xiang-Sun Zhang, Luona...
ISBRA
2007
Springer
14 years 5 months ago
Discovering Relations Among GO-Annotated Clusters by Graph Kernel Methods
The biological interpretation of large-scale gene expression data is one of the challenges in current bioinformatics. The state-of-theart approach is to perform clustering and then...
Italo Zoppis, Daniele Merico, Marco Antoniotti, Bu...