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JCB
2000
107views more  JCB 2000»
13 years 10 months ago
A Discriminative Framework for Detecting Remote Protein Homologies
A new method for detecting remote protein homologies is introduced and shown to perform well in classifying protein domains by SCOP superfamily. The method is a variant of support...
Tommi Jaakkola, Mark Diekhans, David Haussler
BMCBI
2005
127views more  BMCBI 2005»
13 years 10 months ago
Genomes are covered with ubiquitous 11 bp periodic patterns, the "class A flexible patterns"
Background: The genomes of prokaryotes and lower eukaryotes display a very strong 11 bp periodic bias in the distribution of their nucleotides. This bias is present throughout a g...
Etienne Larsabal, Antoine Danchin
GECCO
2006
Springer
162views Optimization» more  GECCO 2006»
14 years 2 months ago
Evolutionary learning with kernels: a generic solution for large margin problems
In this paper we embed evolutionary computation into statistical learning theory. First, we outline the connection between large margin optimization and statistical learning and s...
Ingo Mierswa
CIKM
2009
Springer
14 years 5 months ago
L2 norm regularized feature kernel regression for graph data
Features in many real world applications such as Cheminformatics, Bioinformatics and Information Retrieval have complex internal structure. For example, frequent patterns mined fr...
Hongliang Fei, Jun Huan
JMLR
2010
143views more  JMLR 2010»
13 years 5 months ago
Regularized Discriminant Analysis, Ridge Regression and Beyond
Fisher linear discriminant analysis (FDA) and its kernel extension--kernel discriminant analysis (KDA)--are well known methods that consider dimensionality reduction and classific...
Zhihua Zhang, Guang Dai, Congfu Xu, Michael I. Jor...