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BMCBI
2008
106views more  BMCBI 2008»
13 years 9 months ago
Searching for evolutionary distant RNA homologs within genomic sequences using partition function posterior probabilities
Background: Identification of RNA homologs within genomic stretches is difficult when pairwise sequence identity is low or unalignable flanking residues are present. In both cases...
Usman Roshan, Satish Chikkagoudar, Dennis R. Lives...
BMCBI
2008
86views more  BMCBI 2008»
13 years 9 months ago
Piecewise multivariate modelling of sequential metabolic profiling data
Background: Modelling the time-related behaviour of biological systems is essential for understanding their dynamic responses to perturbations. In metabolic profiling studies, the...
Mattias Rantalainen, Olivier Cloarec, Timothy M. D...
BMCBI
2008
139views more  BMCBI 2008»
13 years 9 months ago
The C1C2: A framework for simultaneous model selection and assessment
Background: There has been recent concern regarding the inability of predictive modeling approaches to generalize to new data. Some of the problems can be attributed to improper m...
Martin Eklund, Ola Spjuth, Jarl E. S. Wikberg
BMCBI
2008
138views more  BMCBI 2008»
13 years 9 months ago
M-BISON: Microarray-based integration of data sources using networks
Background: The accurate detection of differentially expressed (DE) genes has become a central task in microarray analysis. Unfortunately, the noise level and experimental variabi...
Bernie J. Daigle Jr., Russ B. Altman
BMCBI
2008
176views more  BMCBI 2008»
13 years 9 months ago
H2r: Identification of evolutionary important residues by means of an entropy based analysis of multiple sequence alignments
Background: A multiple sequence alignment (MSA) generated for a protein can be used to characterise residues by means of a statistical analysis of single columns. In addition to t...
Rainer Merkl, Matthias Zwick
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