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» Locality and Gaps in RNA Comparison
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BMCBI
2006
120views more  BMCBI 2006»
13 years 7 months ago
Optimizing amino acid substitution matrices with a local alignment kernel
Background: Detecting remote homologies by direct comparison of protein sequences remains a challenging task. We had previously developed a similarity score between sequences, cal...
Hiroto Saigo, Jean-Philippe Vert, Tatsuya Akutsu
BMCBI
2005
100views more  BMCBI 2005»
13 years 7 months ago
Evolutionary models for insertions and deletions in a probabilistic modeling framework
Background: Probabilistic models for sequence comparison (such as hidden Markov models and pair hidden Markov models for proteins and mRNAs, or their context-free grammar counterp...
Elena Rivas
BMCBI
2010
104views more  BMCBI 2010»
13 years 7 months ago
Parameters for accurate genome alignment
Background: Genome sequence alignments form the basis of much research. Genome alignment depends on various mundane but critical choices, such as how to mask repeats and which sco...
Martin C. Frith, Michiaki Hamada, Paul Horton
SIAMAM
2000
71views more  SIAMAM 2000»
13 years 7 months ago
Wave-Block in Excitable Media Due to Regions of Depressed Excitability
We study propagation failure using the one-dimensional scalar bistable equation with a passive "gap" region. By applying comparison principles for this type of equation, ...
James P. Keener, Timothy J. Lewis
BMCBI
2008
132views more  BMCBI 2008»
13 years 7 months ago
The SeqWord Genome Browser: an online tool for the identification and visualization of atypical regions of bacterial genomes thr
Background: Data mining in large DNA sequences is a major challenge in microbial genomics and bioinformatics. Oligonucleotide usage (OU) patterns provide a wealth of information f...
Hamilton Ganesan, Anna S. Rakitianskaia, Colin F. ...