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» Logic-Based Modeling in Systems Biology
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RECOMB
2010
Springer
15 years 11 months ago
Incremental Signaling Pathway Modeling by Data Integration
Constructing quantitative dynamic models of signaling pathways is an important task for computational systems biology. Pathway model construction is often an inherently incremental...
Geoffrey Koh, David Hsu, P. S. Thiagarajan
BMCBI
2010
172views more  BMCBI 2010»
15 years 4 months ago
Comparison of evolutionary algorithms in gene regulatory network model inference
Background: The evolution of high throughput technologies that measure gene expression levels has created a data base for inferring GRNs (a process also known as reverse engineeri...
Alina Sîrbu, Heather J. Ruskin, Martin Crane
IDA
2009
Springer
15 years 2 months ago
Estimating Hidden Influences in Metabolic and Gene Regulatory Networks
We address the applicability of blind source separation (BSS) methods for the estimation of hidden influences in biological dynamic systems such as metabolic or gene regulatory net...
Florian Blöchl, Fabian J. Theis
BIOINFORMATICS
2007
195views more  BIOINFORMATICS 2007»
15 years 4 months ago
Context-dependent clustering for dynamic cellular state modeling of microarray gene expression
Motivation: High-throughput expression profiling allows researchers to study gene activities globally. Genes with similar expression profiles are likely to encode proteins that ma...
Shinsheng Yuan, Ker-Chau Li
WILF
2009
Springer
216views Fuzzy Logic» more  WILF 2009»
15 years 11 months ago
Barycentric Algebras and Gene Expression
Barycentric algebras have seen widespread application in the modeling of convex sets, semilattices, and quantum mechanics. Recently, they were developed further to encompass Boolea...
Anna B. Romanowska, Jonathan D. H. Smith