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» Maximum entropy methods for biological sequence modeling
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BMCBI
2005
201views more  BMCBI 2005»
13 years 9 months ago
Principal component analysis for predicting transcription-factor binding motifs from array-derived data
Background: The responses to interleukin 1 (IL-1) in human chondrocytes constitute a complex regulatory mechanism, where multiple transcription factors interact combinatorially to...
Yunlong Liu, Matthew P. Vincenti, Hiroki Yokota
EDBT
2006
ACM
136views Database» more  EDBT 2006»
14 years 9 months ago
Optimizing Monitoring Queries over Distributed Data
Scientific data in the life sciences is distributed over various independent multi-format databases and is constantly expanding. We discuss a scenario where a life science research...
Frank Neven, Dieter Van de Craen
BMCBI
2010
118views more  BMCBI 2010»
13 years 9 months ago
Detecting lateral gene transfers by statistical reconciliation of phylogenetic forests
Background: To understand the evolutionary role of Lateral Gene Transfer (LGT), accurate methods are needed to identify transferred genes and infer their timing of acquisition. Ph...
Sophie S. Abby, Eric Tannier, Manolo Gouy, Vincent...
KDD
2006
ACM
156views Data Mining» more  KDD 2006»
14 years 9 months ago
Discovering significant OPSM subspace clusters in massive gene expression data
Order-preserving submatrixes (OPSMs) have been accepted as a biologically meaningful subspace cluster model, capturing the general tendency of gene expressions across a subset of ...
Byron J. Gao, Obi L. Griffith, Martin Ester, Steve...
SAC
2009
ACM
14 years 3 months ago
GTfold: a scalable multicore code for RNA secondary structure prediction
The prediction of the correct secondary structures of large RNAs is one of the unsolved challenges of computational molecular biology. Among the major obstacles is the fact that a...
Amrita Mathuriya, David A. Bader, Christine E. Hei...