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BMCBI
2010
141views more  BMCBI 2010»
15 years 4 months ago
BioPhysConnectoR: Connecting Sequence Information and Biophysical Models
Background: One of the most challenging aspects of biomolecular systems is the understanding of the coevolution in and among the molecule(s). A complete, theoretical picture of th...
Franziska Hoffgaard, Philipp Weil, Kay Hamacher
BMCBI
2010
148views more  BMCBI 2010»
15 years 4 months ago
Calling SNPs without a reference sequence
Background: The most common application for the next-generation sequencing technologies is resequencing, where short reads from the genome of an individual are aligned to a refere...
Aakrosh Ratan, Yu Zhang, Vanessa M. Hayes, Stephan...
BMCBI
2010
137views more  BMCBI 2010»
15 years 4 months ago
BS Seeker: precise mapping for bisulfite sequencing
Background: Bisulfite sequencing using next generation sequencers yields genome-wide measurements of DNA methylation at single nucleotide resolution. Traditional aligners are not ...
Pao-Yang Chen, Shawn Cokus, Matteo Pellegrini
BMCBI
2010
117views more  BMCBI 2010»
15 years 4 months ago
Using jackknife to assess the quality of gene order phylogenies
Background: In recent years, gene order data has attracted increasing attention from both biologists and computer scientists as a new type of data for phylogenetic analysis. If ge...
Jian Shi, Yiwei Zhang, Haiwei Luo, Jijun Tang
BMCBI
2010
86views more  BMCBI 2010»
15 years 4 months ago
ICC-CLASS: isotopically-coded cleavable crosslinking analysis software suite
Background: Successful application of crosslinking combined with mass spectrometry for studying proteins and protein complexes requires specifically-designed crosslinking reagents...
Evgeniy V. Petrotchenko, Christoph H. Borchers
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