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BMCBI
2010
126views more  BMCBI 2010»
13 years 6 months ago
Systematic integration of experimental data and models in systems biology
Background: The behaviour of biological systems can be deduced from their mathematical models. However, multiple sources of data in diverse forms are required in the construction ...
Peter Li, Joseph O. Dada, Daniel Jameson, Irena Sp...
BMCBI
2010
218views more  BMCBI 2010»
13 years 6 months ago
A hybrid blob-slice model for accurate and efficient detection of fluorescence labeled nuclei in 3D
Background: To exploit the flood of data from advances in high throughput imaging of optically sectioned nuclei, image analysis methods need to correctly detect thousands of nucle...
Anthony Santella, Zhuo Du, Sonja Nowotschin, Anna-...
BMCBI
2010
154views more  BMCBI 2010»
13 years 6 months ago
Knowledge-based matrix factorization temporally resolves the cellular responses to IL-6 stimulation
Background: External stimulations of cells by hormones, cytokines or growth factors activate signal transduction pathways that subsequently induce a re-arrangement of cellular gen...
Andreas Kowarsch, Florian Blöchl, Sebastian B...
BMCBI
2010
201views more  BMCBI 2010»
13 years 6 months ago
IntelliGO: a new vector-based semantic similarity measure including annotation origin
Background: The Gene Ontology (GO) is a well known controlled vocabulary describing the biological process, molecular function and cellular component aspects of gene annotation. I...
Sidahmed Benabderrahmane, Malika Smaïl-Tabbon...
BMCBI
2010
106views more  BMCBI 2010»
13 years 3 months ago
Identification and correction of previously unreported spatial phenomena using raw Illumina BeadArray data
Background: A key stage for all microarray analyses is the extraction of feature-intensities from an image. If this step goes wrong, then subsequent preprocessing and processing s...
Mike L. Smith, Mark J. Dunning, Simon Tavaré...