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ICGA
1997
122views Optimization» more  ICGA 1997»
13 years 9 months ago
A Comparison of Global and Local Search Methods in Drug Docking
Molecular docking software makes computational predictions of the interaction of molecules. This can be useful, for example, in evaluating the binding of candidate drug molecules ...
Christopher D. Rosin, R. Scott Halliday, William E...
CEC
2010
IEEE
13 years 9 months ago
Learning-assisted evolutionary search for scalable function optimization: LEM(ID3)
Inspired originally by the Learnable Evolution Model(LEM) [5], we investigate LEM(ID3), a hybrid of evolutionary search with ID3 decision tree learning. LEM(ID3) involves interleav...
Guleng Sheri, David Corne
ADHOC
2008
103views more  ADHOC 2008»
13 years 8 months ago
Impact of sensor-enhanced mobility prediction on the design of energy-efficient localization
Energy efficiency and positional accuracy are often contradictive goals. We propose to decrease power consumption without sacrificing significant accuracy by developing an energy-...
Chuang-Wen You, Polly Huang, Hao-Hua Chu, Yi-Chao ...
BMCBI
2010
105views more  BMCBI 2010»
13 years 8 months ago
A knowledge-guided strategy for improving the accuracy of scoring functions in binding affinity prediction
Background: Current scoring functions are not very successful in protein-ligand binding affinity prediction albeit their popularity in structure-based drug designs. Here, we propo...
Tiejun Cheng, Zhihai Liu, Renxiao Wang
BMCBI
2010
129views more  BMCBI 2010»
13 years 8 months ago
Detection of distant evolutionary relationships between protein families using theory of sequence profile-profile comparison
Background: Detection of common evolutionary origin (homology) is a primary means of inferring protein structure and function. At present, comparison of protein families represent...
Mindaugas Margelevicius, Ceslovas Venclovas