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BMCBI
2010
123views more  BMCBI 2010»
13 years 8 months ago
Computationally efficient flux variability analysis
Background: Flux variability analysis is often used to determine robustness of metabolic models in various simulation conditions. However, its use has been somehow limited by the ...
Steinn Gudmundsson, Ines Thiele
TACAS
2007
Springer
99views Algorithms» more  TACAS 2007»
14 years 2 months ago
"Don't Care" Modeling: A Logical Framework for Developing Predictive System Models
Analysis of biological data often requires an understanding of components of pathways and/or networks and their mutual dependency relationships. Such systems are often analyzed and...
Hillel Kugler, Amir Pnueli, Michael J. Stern, E. J...
WABI
2005
Springer
124views Bioinformatics» more  WABI 2005»
14 years 2 months ago
Reconstructing Metabolic Networks Using Interval Analysis
Recently, there has been growing interest in the modelling and simulation of biological systems. Such systems are often modelled in terms of coupled ordinary differential equation...
Warwick Tucker, Vincent Moulton
BMCBI
2006
118views more  BMCBI 2006»
13 years 8 months ago
Predicting the effect of missense mutations on protein function: analysis with Bayesian networks
Background: A number of methods that use both protein structural and evolutionary information are available to predict the functional consequences of missense mutations. However, ...
Chris J. Needham, James R. Bradford, Andrew J. Bul...
RECOMB
2006
Springer
14 years 9 months ago
Assessing Significance of Connectivity and Conservation in Protein Interaction Networks
Computational and comparative analysis of protein-protein interaction (PPI) networks enable understanding of the modular organization of the cell through identification of functio...
Mehmet Koyutürk, Ananth Grama, Wojciech Szpan...