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    BMCBI
    2010
    189views more  BMCBI 2010»
    Efficient parallel and out of core algorithms for constructing large bi-directed de Bruijn graphs
    13 years 8 months ago
    Efficient parallel and out of core algorithms for constructing large bi-directed de Bruijn graphs
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    Background: Assembling genomic sequences from a set of overlapping reads is one of the most fundamental problems in computational biology. Algorithms addressing the assembly probl...
    Vamsi Kundeti, Sanguthevar Rajasekaran, Hieu Dinh,...
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    BMCBI
    2008
    110views more  BMCBI 2008»
    Methylation Linear Discriminant Analysis (MLDA) for identifying differentially methylated CpG islands
    13 years 8 months ago
    Methylation Linear Discriminant Analysis (MLDA) for identifying differentially methylated CpG islands
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    Background: Hypermethylation of promoter CpG islands is strongly correlated to transcriptional gene silencing and epigenetic maintenance of the silenced state. As well as its role...
    Wei Dai, Jens M. Teodoridis, Janet Graham, Constan...
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    BMCBI
    2008
    106views more  BMCBI 2008»
    Comparison of normalisation methods for surface-enhanced laser desorption and ionisation (SELDI) time-of-flight (TOF) mass spect
    13 years 8 months ago
    Comparison of normalisation methods for surface-enhanced laser desorption and ionisation (SELDI) time-of-flight (TOF) mass spect
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    Background: Mass spectrometry for biological data analysis is an active field of research, providing an efficient way of high-throughput proteome screening. A popular variant of m...
    Wouter Meuleman, Judith Y. M. N. Engwegen, Marie-C...
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    BMCBI
    2008
    128views more  BMCBI 2008»
    Pairwise covariance adds little to secondary structure prediction but improves the prediction of non-canonical local structure
    13 years 8 months ago
    Pairwise covariance adds little to secondary structure prediction but improves the prediction of non-canonical local structure
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    Background: Amino acid sequence probability distributions, or profiles, have been used successfully to predict secondary structure and local structure in proteins. Profile models ...
    Christopher Bystroff, Bobbie-Jo M. Webb-Robertson
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    BMCBI
    2008
    167views more  BMCBI 2008»
    Expression profiles of switch-like genes accurately classify tissue and infectious disease phenotypes in model-based classificat
    13 years 8 months ago
    Expression profiles of switch-like genes accurately classify tissue and infectious disease phenotypes in model-based classificat
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    Background: Large-scale compilation of gene expression microarray datasets across diverse biological phenotypes provided a means of gathering a priori knowledge in the form of ide...
    Michael Gormley, Aydin Tozeren
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