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151
Voted
BCB
2010
14 years 10 months ago
2010
A major bottleneck in high-throughput protein crystallography is producing protein-structure models from an electrondensity map. In previous work, we developed Acmi, a probabilist...
153
Voted
BMCBI
2010
14 years 10 months ago
2010
Background: We suggest a new type of modeling approach for the coarse grained, particle-based spatial simulation of combinatorially complex chemical reaction systems. In our appro...
138
Voted
BMCBI
2010
14 years 10 months ago
2010
Background: Shared-usage high throughput screening (HTS) facilities are becoming more common in academe as large-scale small molecule and genome-scale RNAi screening strategies ar...
152
Voted
BMCBI
2010
14 years 10 months ago
2010
Background: Elucidating protein-protein interactions (PPIs) is essential to constructing protein interaction networks and facilitating our understanding of the general principles ...
163
Voted
BMCBI
2010
14 years 10 months ago
2010
Background: The dynamic motions of many proteins are central to their function. It therefore follows that the dynamic requirements of a protein are evolutionary constrained. In or...